(PI; University of Bochum)
Project(s) involved: Gerwert/Herlitze
Curriculum vitae Klaus Gerwert
Prof. Dr., 03.05.1956
Fakultät für Biologie und Biotechnologie
Lehrstuhl für Biophysik
NDEF 04/596
Universitätsstr. 150
44780 Bochum, Germany
Phone +49-0234-32-24461
Email gerwert@bph.rub.de
website: http://www.bph.rub.de/
Education & Scientific Degrees
1975-1981 Diploma (Physics), University of Münster, Germany, Prof.
1985 Dr. rer. nat. (Biophysical Chemistry), Albert-Ludwigs-University Freiburg with Prof. Dr. Josef Ackermann, Prof. Dr. Werner Kreuz, Germany
Research Experience
1986-1990 Post-Doctoral Fellow, Max-Planck-Institute, Dortmund, Germany
1990 „Visiting investigator“, Scripps Research Institute, La Jolla, USA
1990-1993 Heisenberg-Fellow, DFG, Scripps Research Institute, La Jolla, USA, Molecular Biology Department and MPI-Dortmund, Germany
1993 Habilitation (Physical Chemistry), Bielefeld University, Germany. Mentor: Prof. Dr. Eberhard Neumann
Since 1993 Professor (C4;W3 since 2009) and chairman of the Department of Biophysics, Faculty for Biology and Biotechnology, Ruhr University Bochum, Germany
2008-2013 Director at the Max-Planck Partner Institute for Computational Biology, Shanghai, China
Since 2008 “Max-Planck-Fellow” of the Max-Planck society
Honors & Awards
1990 Heisenberg fellowship of the Deutsche Forschungsgemeinschaft
1992 Karl Arnold Jansen Award 1992 of the Rhine-Westphalian Academy of Sciences
2006 Innovation Award Ruhr 2006, Award of the prime minister of North Rhine-Westphalia, Alfried Krupp von Bohlen and Halbach foundation
2008-present Member of the North Rhine-Westphalian Academy of Sciences
Selected Publications
1) El-Mashtoly, S.F., Yosef, H.K., Petersen, D., Mavarani, L., Maghnouj, A., Hahn, S.A., Kötting, C. and Gerwert, K. (2015) Label-free Raman spectroscopic imaging monitors the integral physiologically relevant drug responses in cancer cells. Anal. Chem. 87, 7297-7304.
2) Gavriljuk, K., Gazdag, E. M., Itzen, A., Kötting, C., Goody, R. S., Gerwert, K. (2012) Catalytic Mechanism of a Mammalian Rab•RabGAP Complex in Atomic Detail. Proc. Natl. Acad. Sci., 109 (52), 21348-21353.
3) Rudack, T., Fei X., Schlitter, J., Kötting, C. and Gerwert, K. (2012) Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc. Natl. Acad. Sci. 109, 15295-15300.
4) Freier, E., Wolf, S. and Gerwert, K. (2011) Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc. Natl. Acad. Sci., 108 (28), 11435-11439
5) Wolf, S., Freier, E., Potschies, M., Hofmann, E. and Gerwert, K. (2010) Directional Proton Transfer in Membrane Proteins Achieved through protonated Protein-Bound Water Molecules: Angew. Chem. Int. Ed., 49, 6889-6893
6) Elfrink, K., Ollesch, J., Stöhr, C., Willbold, D., Riesner, D., Gerwert, K. (2008) Structural changes of membrane anchored PrPC. Proc. Natl. Acad. Sci., 105, No. 31, 10815-10819.
7) Kötting, C., Kallenbach A., Suveyzdis, Y., Wittinghofer, A. Gerwert, K. (2008) The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc. Natl. Acad. Sci., 105, No. 17, 6260-6265.
8) Garczarek, F., Gerwert, K. (2006) Functional Waters in Protein Proton Transfer. Nature, 439, 109-112.
9) Remy, A., Gerwert, K. (2003) Coupling of light-induced electron transfer to proton uptake in photosynthesis. Nature Struct. Biol., 10, 637–644.
10) Brudler, R., Rammelsberg, R., Woo, T.T., Getzoff, E.D., Gerwert, K. (2001) Structure of the I1 early intermediate of photoactive yellow protein by FTIR spectroscopy. Nature Structural Biology, 8, no. 3, 265 – 270.