(PI; University of Göttingen)
Project(s) involved: Gerwert/Herlitze/Brügmann
herzzentrum.umg.eu/forschung/arbeitsgruppen/vegetative-optogenetik/
Juniorprof. Dr. med., 7.9.1984
Universitätsmedizin Göttingen
Institut für Herz- und Kreislaufphysiologie
Humboldtallee 23
37073, Göttingen, Germany
Phone +49-0551-39-5880
Email tobias.bruegmann@med.uni-goettingen.de
Publications
1) Bruegmann, T., Malan, D., Hesse, M., Beiert, T., Fuegemann, C. J., Fleischmann, B. K., Sasse, P. (2010) Optogenetic control of heart muscle in vitro and in vivo. Nat Methods, 7(11):897-900.
2) Beiert, T., Bruegmann, T., Sasse, P. (2014) Optogenetic activation of gq signalling modulates pacemaker activity of cardiomyocytes. Cardiovasc. Res., 102(3):507-516.
3) Vogt, C. C.,* Bruegmann, T.,* Malan, D., Ottersbach, A., Roell, W., Fleischmann, B. K., Sasse, P. (2015) Systemic gene transfer enables optogenetic pacing of mouse hearts. Cardiovasc. Res., 106(2):338-343.
4) Bruegmann, T., van Bremen, T., Vogt, C. C., Send, T., Fleischmann, B. K., Sasse, P. (2015) Optogenetic control of contractile function in skeletal muscle. Nat. Commun., 6:7153.
5) Bruegmann, T.,* Boyle, P. M.,* Vogt, C. C., Karathanos, T. V., Arevalo, H. J., Fleischmann, B. K., Trayanova, N. A., Sasse, P. (2016) Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations. J. Clin. Invest., 126(10):3894-3904.
6) van Bremen, T., Send, T., Sasse, P., Bruegmann, T. (2017) Spot light on skeletal muscles: Optogenetic stimulation to understand and restore skeletal muscle function. J. Muscle Res. Cell. Motil., 38(3-4):331-337
7) Rehnelt, S., Malan, D., Juhasz, K., Wolters, B., Doerr, L., Beckler, M., Kettenhofen, R., Bohlen, H., Bruegmann, T.,* Sasse, P.* (2017) Frequency-dependent multi-well cardiotoxicity screening enabled by optogenetic stimulation. Int. J. Mol. Sci., 18(12).
8) Lapp, H., Bruegmann, T., Malan, D., Friedrichs, S., Kilgus, C., Heidsieck, A., Sasse, P. (2017) Frequency-dependent drug screening using optogenetic stimulation of human ipsc-derived cardiomyocytes. Sci. Rep., 7(1):9629.
9) Bruegmann, T.,* Beiert, T.,* Vogt, C. C., Schrickel, J. W., Sasse, P. (2018) Optogenetic termination of atrial fibrillation in mice. Cardiovasc. Res., 114(5):713-723.
10) Fehrentz, T., Huber, F. M. E., Hartrampf, N., Bruegmann, T., Frank, J. A., Fine, N. H. F., Malan, D., Danzl, J. G., Tikhonov, D. B., Sumser, M., Sasse, P., Hodson, D. J., Zhorov, B. S., Klocker, N., Trauner, D. (2018) Optical control of l-type ca(2+) channels using a diltiazem photoswitch. Nature Chem. Biol.,14(8):764-767.
* equal contribution