(PI; ZMNH, University of Hamburg)
Project(s) involved: Soba/Wiegert
Curriculum Vitae
Center for Molecular Neurobiology Hamburg (ZMNH)
Falkenried 94, 20251 Hamburg, Germany
Phone: +49 (0) 40 741055085
Email: simon.wiegert@zmnh.uni-hamburg.de
ACADEMIC POSITIONS
Since 01/2016 Principal Investigator at the ZMNH Hamburg, Germany
02/2012-present Senior postdoctoral fellow at the ZMNH Hamburg, Germany
Institute for Synaptic Physiology, laboratory of Prof. Thomas Oertner
09/2009-02/2012 Postdoctoral fellow at the Friedrich-Miescher Institute Basel, Switzerland
Department of Neurobiology, laboratory of Dr. Thomas Oertner
04/2009-08/2009 Postdoctoral fellow at the University of Heidelberg, Germany
Interdisciplinary Center for Neurosciences, laboratory of Prof. Hilmar Bading
EDUCATION
11/2005-03/2009 PhD thesis at the University of Heidelberg, Germany
Interdisciplinary Center for Neurosciences, laboratory of Prof. Hilmar Bading
Title: “Synaptic plasticity in hippocampal neurons: Investigation of the transcription-dependent regulation of synaptic connectivity and ERK-mediated synapse-to-nucleus communication”
08/2003-02/2004 Internship at the Monash University, Melbourne, Australia
Monash Institute for Medical Research, laboratory of Prof. Ban-Hock Toh
2001-2005 Research assistant at MPI for Medical Research, Heidelberg, Germany, laboratory of Prof. Bert Sakmann
10/2000-11/2005 Diploma in Biology at the University of Heidelberg, Germany
Thesis: “Live imaging of ERK nuclear translocation and analysis of the role of gene transcription in activity induced enhancement of synaptic efficacy in hippocampal neurons in culture” Mark: 1.0 with distinction
GRANTS / FELLOWSHIPS / AWARDS
2015 Abstract selected for Hot Topic book by Society for Neuroscience
2013, 2014 2x ‘Paper of the month’ selected by the University Medical Centre Hamburg-Eppendorf
2010 - 2012 Marie-Curie Postdoctoral Fellowship from EU/FP7
2008 - 2014 Travel grants awarded by the German Academic Exchange Service (DAAD), German Neuroscience Society (NWG) & “Deutsche Forschungsgemeinschaft” (DFG)
2005 Diploma in Biology with Distinction
PUBLICATIONS
1) Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5:14807
2) Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Vetter, T., Oertner, T.G. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97
3) Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412, *first 2 authors equally contributing
Highlighted in Science, Science Signaling & Nature Methods
4) Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024
5) Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519.
6) Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478.
7) Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980.
8) Wittmann, M. *, Queisser, G. *, Eder, A. *, Wiegert, J.S. *, Bengtson, C.P. *, Hellwig, A. *, Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. *first 6 authors equally contributing
9) Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124.
10) Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633.
Review articles:
1) Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus: basis for morphology modulation of nuclear calcium signaling and gene transcription. Nucleus 2(2), 1-7.
2) Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305.